Welcome to the Natural Medicine Division at the Colorado Department of Revenue!

The licensing and regulation of natural medicines in Colorado falls under two state agencies: the Department of Revenue (DOR) and the Department of Regulatory Agencies (DORA). The responsibilities of each agency are highlighted below. DOR will license and regulate businesses related to natural medicine and DORA will regulate and license facilitators (people).

Under SB23-290:

DOR’s new Natural Medicine Division is responsible for licensing and regulating healing centers, cultivations, manufacturers, and testing facilities. In addition, the Natural Medicine Division is assigned the following responsibilities:

  • Creating a testing and certification program (in coordination with the Colorado Department of Public Health and Environment)
  • Collecting and reporting available data collection (such as adverse health events, healthcare system impacts, consumer protection claims)
  • Creating public education campaigns
  • Providing training materials for first and multi-responders

DORA will license and regulate Facilitators (persons licensed to provide natural medicine and related services), as well as continue facilitating the:

  • Natural Medicine Advisory Board
  • Federally Recognized Tribes & Indigenous Community Work Group


Natural Medicine legislative history

On Nov. 5, 2022, Colorado voters approved Proposition 122: Access to Natural Psychedelic Substances. The ballot measure directed the Governor to appoint members to the Natural Medicine Advisory Board and the Colorado Legislature and the Department of Regulatory Agencies (DORA) to develop an infrastructure for Colorado's Natural Medicine Health Act, as informed by Advisory Board recommendations. 

In April, Senate Bill (SB) 23-290: Natural Medicine Regulation and Legalization was introduced and, following the legislative process, was signed by Governor Polis on May 23, 2023. 
The Final Act tasked the Department of Revenue with creating a Natural Medicine Division to license and regulate the cultivation, manufacturing, distribution, and testing of regulated natural medicine and regulated natural medicine products in Colorado.
The Natural Medicine Division will work closely with DORA and the Natural Medicine Advisory Board, facilitated by DORA, to develop rules and processes.

Additional information:


Contact Us


Senior Director

Dominique Mendiola
Senior Director

Director of Policy & Regulatory Affairs

Allison Robinette
Director of Policy & Regulatory Affairs

Media Contact

Shannon Gray
Communications Supervisor